Doxycycline Induced Esophageal Ulcer: The Report of Two Cases

It has been established that drugs can induce esophageal mucosal injury. Doxycycline induced esophageal injury has contributed to most of drug induced esophageal injuries. In this study, two cases were presented. Two females who were 27 and 30 years old, applied to our hospital with complains of an acute onset odynophagia, dysphagia and retrosternal pain after using doxycycline for their genital system infection. Endoscopic examination detected semicircular deep ulceration at the middle esophagus. Their symptoms improved after 3 days of initiation of pantoprazole and liquid sucralfate following discontinuation of doxycycline. Drug induced esophageal injury is a common condition. Use of drug should be investigated in patients with similar symptoms.